A pregnancy loss is devastating no matter when it occurs; however, definitions matter for diagnostics and medicine. The American Society for Reproductive Medicine defines recurrent pregnancy loss as the loss of two or more clinical pregnancies before the 20th week. But what exactly does this mean?
A known cause, or "etiology" can be identified many families experiencing RPL. Those causes are depicted on the right side of the image below and discussed on the Causes and Treatments page.
However, in roughly 50% of cases, the cause of RPL is unknown, or "idiopathic." The depictions on the left side of the image represent factors that have been associated with recurrent miscarriage, but require more study.
Reprinted by permission from Springer Nature: Springer US, Journal of Assisted Reproduction and Genetics, "Genetic and Epigenetic Variations Associated with Idiopathic Recurrent Pregnancy Loss," Luis Alejandro Arias-Sosa et al, © 2018